DOMINO: doxycycline 40 mg vs minocycline 100 mg for rosacea (2017)

Eighty people with rosacea were randomly given either doxycycline 40 mg or minocycline 100 mg for 16 weeks. Lesion counts fell by a similar amount in both groups — 13 versus 14 fewer lesions — which was the question the trial was designed to answer. Minocycline scored better on the doctor's overall assessment and on relapse, but those were secondary measures the trial was not built to test, so they are suggestive rather than settled. Only the assessors were blinded, not the patients.