RCT

Ivermectin keeps rosacea clear longer than metronidazole (ATTRACT, 2016)

After treatment stopped, people who had used ivermectin stayed clear a median of 115 days versus 85 days on metronidazole.

Written & medically reviewed by a board-certified dermatologist

This followed people whose rosacea had already cleared, to see how long it stayed away after stopping treatment. Those originally treated with ivermectin went a median of 115 days before relapsing, against 85 days for metronidazole. Worth reading the other number too: most people in both groups relapsed eventually (62.7% vs 68.4%), so the difference is in how long the clear spell lasts, not whether it ends. Manufacturer-funded.

Taieb A, Khemis A, Ruzicka T, et al. Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study. J Eur Acad Dermatol Venereol. 2016;30(5):829-836.

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