Oxymetazoline cream for facial redness (REVEAL 2 RCT, 2018)

445 people with lasting facial redness from rosacea were randomly given oxymetazoline 1% cream or an identical cream without the drug, once a day for 29 days. More people on the active cream improved by at least two grades on both the doctor's and their own rating, held across 3, 6, 9 and 12 hours after applying. Digital photo analysis agreed. Two points are worth knowing: the drug narrows blood vessels, so it covers redness rather than treating what causes it, and only 2 of 445 people had redness rebound after stopping — a common worry with this class. Manufacturer-funded.