If you are choosing a lip filler, the product to ask about from Prollenium is Revanesse Lips+, not Revanesse Versa. Versa's FDA approval is for facial wrinkles and folds such as nasolabial folds. The lip approval in that family went to a separate product, Revanesse Lips+, on 21 September 2020.
On the other side, only two Juvederm products carry a US lip approval. Juvederm Ultra XC gained one on 30 September 2015 and Juvederm Volbella XC on 31 May 2016. Juvederm Ultra Plus XC, Voluma XC, Vollure XC, Volux XC and Skinvive do not have a lip indication, which is why "Juvederm for lips" is not a single answer.
No trial has compared a Revanesse product with a Juvederm product. Both families ran their own trials against their own comparators, and in the Revanesse trials the FDA record does not even name what the comparator was. Nothing published lets anyone say one of these gives a better lip result.
What is documented is the syringe size, the anaesthetic and the length of the published follow-up. Revanesse syringes hold 1.2 mL; the Juvederm lip products hold 1.0 mL or 0.55 mL. Revanesse Lips+ was followed for 6 months in its trial; the two Juvederm lip products were followed for 12 and 13 months.
Revanesse Versa's own approval, granted in 2017, is for facial wrinkles and folds such as nasolabial folds. It is not a lip approval.
Juvederm Ultra Plus XC has no US lip indication, despite how often it is described as the stronger lip option.
Plain Revanesse Versa contains no lidocaine. Revanesse Lips+ and Versa+ do.
Volbella XC is the least concentrated gel in the Juvederm range.
FDA approved the increase from 1.0 mL to 1.2 mL for Versa and Versa+ in March 2019, and for Lips+ in May 2021.
The 0.55 mL fill was approved for Volbella XC in 2016 and for Ultra XC in 2019.
158 people, double-blind and randomised, follow-up 6 months. The comparator is described only as an FDA-approved filler containing lidocaine; the FDA record does not name it.
Ultra XC's trial ran 12 months against an untreated control group. Volbella XC's ran 13 months against Restylane-L.
The Lips+ protocol allowed 1.5 mL per lip plus 1.0 mL for lines around the mouth. The average amount actually used is not reported.
Revanesse products were not included in that test, so nothing is published about how they compare.
Both of these are brand families, and inside each family the lip approval sits with particular products. If someone offers you "Versa in the lips", that is off-label use of a product approved for folds. Off-label injection is legal and routine in the US, and injectors do it every day for good reasons. But it is worth knowing which you are being given, because the trial evidence follows the approval, not the brand.
The same applies in reverse. Juvederm Ultra Plus XC is widely described online as the firmer lip option, and it has no US lip indication at all. Its approval covers facial wrinkles and folds only.
Every figure above is a responder rate: the share of people judged to have improved by at least one grade on a scale the manufacturer developed. Prollenium, Allergan and Galderma each use their own lip scale, so the numbers are not interchangeable even when they describe the same part of the face.
The other thing worth noticing is where each number lands at the end. Juvederm Ultra XC's lip figure falls from 79.1% at month 3 to 56.4% at month 12 — meaning that by the last visit, close to half the treated group no longer met even a one-grade improvement. That is what "lasts up to a year" is built on. It is the edge of the follow-up window, not a typical result.
Revanesse Lips+ has no 12-month figure at all, because its trial stopped at 6 months.
Swelling, bruising and tenderness are the normal picture after lip injection, and the best hard numbers come from filler trials rather than from clinic copy. In one under-eye trial, tenderness was reported by 49.5%, bruising by 42.7% and swelling by 41.7% of participants, mostly mild and settling within a week. Lips swell more than most areas.
Nodules, not migration, are the most commonly reported lip filler complication: A review of 53 cases and 82 complications found lump formation the most frequent problem, with migration, discoloration and cold sore flares also linked to lip placement. There is no published rate for lip filler migration; the literature on it is case reports and hospital series.
If you get cold sores, say so when you book rather than on the day, because antiviral medicine has to be started in advance.
There is no current published per-syringe price from any professional society. The last figure the American Society of Plastic Surgeons published for lip augmentation with injectable materials was $698, for the data year 2023 — after which ASPS stopped reporting fees for minimally invasive procedures. That figure is a surgeon or physician fee only, excludes facility costs, and is an average per procedure rather than per syringe.
RealSelf, which crowdsources what patients say they paid, listed an average of $660 for lip filler from 264 patient reviews, updated 27 September 2024. Those are self-selected reviewers rather than a survey, and the figure covers a whole treatment visit.
Neither Prollenium nor Allergan publishes a patient price.
Go to an emergency department or call 911 if any of these happen during or after a filler injection:
Sudden change or loss of vision in one or both eyes
Pain that is far worse than the procedure should reasonably cause
Skin that goes white or pale in a patch, then turns dusky, grey or mottled
Weakness on one side, a drooping face, slurred speech or confusion
These are the signs of filler entering a blood vessel. Published guidance treats a suspected eye event as a same-hour emergency and a suspected skin event as a same-day one. One caution about pain: in a survey of 52 experienced injectors, pain was mild or absent in 47% of the intravascular events they reported. Pain is not a reliable alarm, and its absence is not reassurance.
Swelling is still growing after the first few days instead of settling
A lump has not softened
Redness is spreading outward from an injection site
Tenderness, swelling or a new lump appears weeks or months later, which can mean a delayed inflammatory reaction or an infection
The filler looks like it has shifted out of place
None of these are emergencies, but none of them should be left alone either.