Comparison

Xerf vs Thermage

Thermage is monopolar radiofrequency with no needles, cleared for periorbital wrinkles including the upper and lower eyelids and for facial wrinkles. For XeRF, published evidence and US regulatory status could not be established, so this page sets out what to ask instead.
Written & medically reviewed by the Dermapedia team
At a Glance

Only one of these two has a record we can show you. "XeRF" does not appear in the published literature, and we could not match it to an FDA record. We could not establish who makes it, whether it holds a US clearance, what any clearance covers, what frequency or power it runs at, or whether it uses needles. Rather than guess at any of that, this page sets out what is verifiable about monopolar radiofrequency tightening as a category, what Thermage's paperwork actually says, and exactly what to ask a clinic to close the gap.

Thermage is documented in detail, and one part of that documentation is unusual. The ThermaCool System clearance (K052936, 12 June 2007) reads: "Dermatologic and general surgical procedures for electro coagulation and hemostasis" - surgical language for sealing tissue and stopping bleeding - then "Non-invasive treatment of periorbital wrinkles and rhytids including the upper and lower eyelids" and "Non-invasive treatment of facial wrinkles and rhytids". The Thermage FLX clearance (K170758, 22 September 2017) carries the same first two lines for radiofrequency energy alone, and broadens the third from facial wrinkles to "non-invasive treatment of wrinkles and rhytids".

Naming the eyelid is the part worth noticing. No radiofrequency microneedling clearance names the eyelid or the periorbital area, so needle-based radiofrequency treatment near the eye is off-label. Thermage's clearance names it directly. That does not mean Thermage works well around the eyes - a 510(k) clearance is a finding that a device is similar enough to an earlier one, not a demonstration of benefit. It means a regulator reviewed the device for that area, which is a real difference in what has been looked at.

Thermage's mechanism is well understood, and it is the honest baseline for any monopolar RF device. Current passes from a single treatment tip through the tissue to a return electrode on the patient's back. The skin's own resistance to that current generates heating throughout the dermis and into the fibrous bands beneath it, while a cryogen spray keeps the surface cool. Collagen fibres contract at coagulative temperature and then remodel over the following months. It runs at 6.78 MHz with a maximum average power of 400 W, and the tip is applied in a stamping motion rather than glided.

XeRF
manufacturer and clearance not established
Thermage / Thermage FLX
Solta, monopolar radiofrequency

What it is

Not established here

We could not confirm the manufacturer, the technology type, whether needles are involved, or the US regulatory status.

A non-invasive monopolar radiofrequency treatment. No needles, nothing breaks the skin

The tip is stamped across the treatment area with cryogen cooling of the surface between pulses.

Both
The first thing to establish about any device called "RF" is whether it is needle-based. That single fact changes the recovery, the risk list and the aftercare completely.

How it works

Not established here

Monopolar radiofrequency in general heats tissue by passing current through it to a return electrode, using the tissue's own resistance to generate heat. Whether this device works that way, at what frequency and with what cooling, is not something we could confirm.

Bulk volumetric heating of the dermis and the fibrous bands beneath it, at 6.78 MHz

Cryogen spray protects the surface while the deeper tissue heats. Collagen contracts immediately at coagulative temperature and remodels over the following months.

How deep it goes

Not established here
Not depth-selectable in the way a needle device is

Monopolar radiofrequency heats a volume rather than a chosen plane, hottest in the upper dermis with the surface cooled. That makes it broadly usable across skin types, and much less controllable in depth than a needle-based device.

What it is cleared to treat

Not established here

We could not confirm a US clearance, so no number and no indication wording is quoted. That is not a claim that none exists.

Electrocoagulation and hemostasis; periorbital wrinkles including the upper and lower eyelids; facial wrinkles

Those are the cleared words, from K052936 in 2007 and repeated for radiofrequency alone in the Thermage FLX clearance K170758 in 2017. A separate mode combining radiofrequency with skin vibration adds temporary improvement in the appearance of cellulite, relief of minor muscle aches and spasms, and temporary improvement of local circulation.

Both
If a clinic tells you a device is FDA cleared, ask under what number and for what exact wording. "FDA cleared" alone says nothing about which body area or which effect - and clearance is a similarity finding, not proof of benefit.

Downtime

Not established here
Effectively zero. Transient redness and swelling

Results build over roughly two to six months. This is the conventional clinical description, not a figure stated in the Indications for Use.

Sessions

Not established here
Usually one, with the result developing over the following months

Not a labelled figure.

Who tends to be happy with it

Best for
Someone who has already got the answers this page could not: the manufacturer, the clearance number, the indication wording and whether needles are involved.
The mindset
Get it in writing before the appointment.
Best for
Someone who wants mild tightening with no needles, no recovery and no restriction on normal life, including around the eyes, and who is content with a gradual and modest change.
The mindset
One session, nothing to hide from, patience for a few months.

What to ask a clinic offering XeRF

Six questions. The first two matter most:

  1. Who manufactures it, and does it hold a US FDA clearance? What is the number? Then read the Indications for Use yourself - FDA clearance documents are public.
  2. Does it use needles? A needle-based radiofrequency device and a non-needle one are different treatments with different recoveries, different risks and different aftercare, even though both are correctly called "RF".
  3. Is it monopolar or bipolar, and at what frequency? Monopolar sends current through tissue to a return electrode; bipolar keeps it between electrodes in the tip.
  4. How is my skin surface protected? Thermage uses cryogen cooling. Ask what this device uses.
  5. What published evidence exists for this specific device? Not for radiofrequency in general. For this machine.
  6. How many sessions, at what interval, and what does the full course cost?

If a clinic cannot answer the first question, that is itself an answer about how much is knowable.

What monopolar RF tightening does and does not do

Worth being realistic about the category, whichever device is in the room.

It heats the dermis and the fibrous bands underneath through intact skin. Collagen contracts and then remodels, so the change is gradual and modest rather than dramatic, and it arrives over months rather than days. It is broadly usable across skin types, because radiofrequency heating does not depend on pigment the way light-based treatments do.

What it does not do: it cannot treat surface texture or scarring at all, because it does not injure the surface. It cannot be dialled to a chosen depth the way a needle device can, because it heats a volume rather than a plane. And it does not replace lost volume.

Documented rare adverse events with Thermage are burns, blistering, and subcutaneous fat atrophy producing visible depressions. Those figures are not quantified in the published literature, so no incidence is given.

Before you book

Tell your provider if you have a pacemaker or an implantable defibrillator, or any metal implant near the area to be treated. Radiofrequency current can interfere with cardiac devices and can be conducted by metal, causing focal heating. These are labelled contraindications for radiofrequency devices generally. They are precautionary rather than tested - no published study has treated patients with cardiac implants - and the right people to advise you are your cardiology team, not a clinic.

If you get cold sores, say so when you book, not on the day. Antiviral medicine is started in advance, so it has to be prescribed before the appointment. Neither of these treatments is described as breaking the skin, and there is no published data on cold-sore reactivation after radiofrequency tightening specifically - the precaution is carried over from laser resurfacing, where reactivation is well documented. It is your provider's call, which is why they need to know beforehand.

Also mention current or previous skin cancer in the treatment area, and any severe cardiac condition.

Get emergency help now

Neither treatment is described as breaking the skin, so infection is unlikely. If a burn or blister does occur and then shows signs of spreading infection, treat that as urgent rather than routine:

  • Fever after treatment
  • Redness spreading outward from a burnt or blistered area
  • Pus or discharge from broken skin
  • Increasing pain with skin that is hot and hard to the touch

Call your provider if

  • A blister, burn or open area appears on treated skin
  • Redness or swelling increases after the first day or two instead of settling
  • Pain during treatment is severe rather than a strong heat sensation - say so at the time, because that is how burns are avoided
  • An area starts to look hollow, dented or deflated compared with the other side over the following weeks
  • Numbness in the treated area does not begin to recover
  • A cluster of small painful blisters appears, which can be a cold sore flare

Related

Questions people ask+
What is XeRF?We could not establish that. No manufacturer, no clearance and no published study could be matched to the name. The manufacturer, the US regulatory status, the specifications and whether it uses needles are all unconfirmed here, so nothing about it is asserted on this page. Ask the clinic for the manufacturer and the FDA clearance number.
Is XeRF FDA cleared?Unknown to us. No clearance could be established either way, which is not the same as saying none exists. The clearance number is a fair thing to ask for, and the Indications for Use text behind it is public.
What is Thermage cleared for?Its clearance names electrocoagulation and hemostasis, non-invasive treatment of periorbital wrinkles and rhytids including the upper and lower eyelids, and non-invasive treatment of facial wrinkles and rhytids (K052936, 2007, repeated in the Thermage FLX clearance K170758 in 2017). A mode combining radiofrequency with skin vibration adds temporary improvement in the appearance of cellulite and some muscle and circulation claims.
Does Thermage use needles?No. It is monopolar radiofrequency delivered through the surface with a tip stamped across the skin, with cryogen cooling to protect the epidermis. Nothing penetrates.
Does clearance mean Thermage works?No. A 510(k) clearance means the FDA agreed a device is substantially equivalent to one already on the market. It is not a finding that a benefit was demonstrated. What the clearance does tell you is which uses a regulator has looked at.
How many Thermage sessions do I need?Conventionally one, with the result developing over roughly two to six months as collagen remodels. That is clinical description rather than a labelled figure.
I have a pacemaker. Can I have radiofrequency treatment?Cardiac implantable devices are a labelled contraindication for radiofrequency devices generally, because the current can interfere with them. The same applies to metal implants near the treatment area. This is precautionary rather than tested, and the decision belongs with your cardiology team, not with a clinic.