Comparison

PRP vs Botox

Botox relaxes the muscle that creases skin and works in days. PRP uses your own platelets for skin quality or hair, over months. How to choose.
Written & medically reviewed by the Dermapedia team
At a Glance

Botox is the answer for lines that appear when you move your face. It relaxes the muscle that folds the skin, works within a few days, and lasts three to four months. PRP is the answer for skin quality or thinning hair. It uses your own blood, works slowly over months, and takes a course of three or more visits. They are not rivals, and neither one does the other's job.

PRP
Also called platelet-rich plasma, vampire facial, PRP facial, PRP for hair
Botox
Also called botulinum toxin, Dysport, Xeomin, Jeuveau, tox, neurotoxin

What it is

Concentrated cells from your own blood

Blood is drawn, spun in a machine to separate the platelets, and the platelet-rich part is injected back. Platelets release growth factors as they heal an injury.

A purified protein that relaxes muscle

It blocks the signal from nerve to muscle in the small area where it is placed.

What problem it fixes

Skin quality and thinning hair

Dullness, fine crepey lines, some acne scarring, and hair that is thinning but not gone. Most PRP in the world is used on scalps.

Lines made by movement

Frown lines, forehead lines and crow's feet. Also jaw clenching, underarm sweating and some headaches.

How soon it works

Three to six months

Hair often stops shedding first, then thickens. Skin changes are gradual and easy to miss week to week.

Three to seven days

Fully settled at two weeks. You will see it in the mirror.

How long it lasts

Months, with repeat visits

Most plans include maintenance every four to six months, indefinitely.

Three to four months

Then the muscle wakes up and the line comes back.

How many visits

Three to six to start

Spaced about a month apart, then maintenance.

One, then repeat

Fifteen minutes. Most people go three or four times a year.

What it feels like

A blood draw, then injections

The blood draw is the part people dread and the easy part. Scalp injections sting. Numbing is usual.

A few quick pinches

Very fast. Most people skip numbing cream entirely.

Downtime and side effects

Soreness, swelling, bruising, a day or two

Because it is your own blood, an allergic reaction is not a concern.

Small bumps for an hour, sometimes a bruise

A drooping lid or brow happens occasionally, wears off, and is more likely with an inexperienced injector.

What it will not do

It will not soften a frown line

PRP does nothing to muscle. A crease made by movement stays.

It will not improve skin quality

Skin can look smooth in the frown area and still be dull, rough or thinning.

Cost

More expensive, and it is a course

Priced per session with several sessions to start. Ask for the cost of the whole plan.

Priced per unit or per area

One appointment at a time, so the number is easy to pin down. It repeats a few times a year.

The at-home or drugstore version

None, and no cream matches it

The active part comes from your own blood and must be spun down in a machine. Nothing sold as a growth factor serum is the same thing.

Nothing comes close

Creams marketed as "Botox in a bottle" sit on the surface. A muscle sits several millimetres below it, and nothing you rub on reaches it.

Who each suits

Best for
Early hair thinning, or skin that looks tired rather than lined.
The mindset
You will do a course and wait months to judge it.
Best for
Lines between the brows, across the forehead or beside the eyes.
The mindset
You want a clear change within a week.

They are treating different things

Botox works on muscle: A frown line is a fold made by a muscle pulling the same way thousands of times. Relax that muscle and the fold stops being made, so the line softens over the following weeks.

PRP works on tissue quality: It is used where you want skin or hair follicles to behave better, not where you want a muscle to stop pulling.

That is why a clinic may suggest both: They act in different places, and using one does not use up the other.

Which one for a line on your face

Ask yourself whether the line is there when your face is still: If it only appears when you frown or smile, that is a movement line, and botulinum toxin is the treatment for it.

A line that sits there when your face is relaxed is a different problem: These respond better to resurfacing, filler or a collagen treatment. PRP may help the skin around them look better, but it will not erase them.

PRP for hair is where it is used most

Most PRP is done on scalps, not faces: It is offered for thinning hair that is still producing fine hairs, and it works best early.

It does not bring back hair from a bald scalp: Once follicles are gone, no injection restores them.

It is usually added to treatment rather than replacing it: Minoxidil and finasteride have far more evidence behind them, and most plans use PRP alongside one of those, not instead.

Has anyone compared them directly

No trial has compared PRP with Botox, because there is nothing to compare: They treat different problems, and no sensible study would put them head to head.

Before you book

Decide what you want fixed first. Movement lines and skin quality lead to two different answers.

For PRP, ask for the total cost of the course and what happens if the first course does nothing.

For PRP on the scalp, ask what else is in the plan. On its own it is rarely the whole answer.

For botulinum toxin, ask how many units you are getting and where.

Ask to see photos of the injector's own work rather than photos from a brochure.

Related

Questions people ask

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Can PRP replace Botox?No. PRP does nothing to muscle, so it will not soften a frown line or a forehead line. It works on skin quality and hair, which Botox does not touch.
Can you have PRP and Botox together?Yes. They act in different places and are often done in the same plan, sometimes at the same appointment. Ask your injector about the order and spacing.
Which one is better for wrinkles?Botox, for lines caused by movement. For fine crepey lines that are there when your face is still, neither one is ideal, and resurfacing or a collagen treatment is the better question to ask about.
Does PRP really work for hair loss?It helps some people with early thinning, and results build over three to six months. It does not regrow hair on a bald scalp, and it is usually added to minoxidil or finasteride rather than used instead of them.
Which costs more?PRP, in most cases, because it starts as a course of three to six sessions and continues with maintenance. Botox is one short appointment repeated a few times a year.
How long does each last?Botox lasts three to four months, then the line returns. PRP results build slowly and are kept up with a session every four to six months.