Comparison

Varithena vs Sclerotherapy

Varithena is a ready-made foam for large varicose veins. Sclerotherapy treats spider veins and small surface veins. Visits, downtime and cover.
Written & medically reviewed by the Dermapedia team
At a Glance

Varithena is a ready-made foam for large varicose veins, including the trunk vein under the skin. It is injected with ultrasound guiding it, usually in one visit. Plain sclerotherapy is better for spider veins and small surface veins. It is a course of injections spaced weeks apart. Both use the same kind of drug, so the real question is vein size, not brand.

Varithena
Also called polidocanol endovenous microfoam, foam sclerotherapy, chemical ablation
Sclerotherapy
Also called liquid sclerotherapy, spider vein injections, microsclerotherapy

What it is

A manufactured foam

Polidocanol mixed into a fine, even foam in a canister. The bubbles push blood out of the way so the drug touches the vein wall directly.

A liquid, or a hand-mixed foam

The same family of drug in liquid form. For medium veins many doctors whip their own foam at the bedside with a syringe.

Which veins it is for

Large veins, including the trunk vein

Twisted trunk veins and big branches, usually found on ultrasound rather than by eye.

Spider veins and small varicose veins

The fine red and purple lines, and small ropey veins you can see near the surface.

How it is done

Needle or catheter, plus ultrasound

The leg is scanned while the foam is injected, so the doctor can watch it fill the vein and spasm it shut. No heat, and no numbing fluid along the vein.

Freehand injections into what you see

Several small injections per visit, sometimes with a light or vein finder to spot feeding veins.

What it feels like

Pressure, then an aching leg

The injection itself is quick. Legs often feel tight or achy for a few days afterwards.

Stinging, then a brief cramp

Each injection stings for a second. Some solutions cause a short cramping ache.

How many visits

Often one, sometimes two

A follow-up scan checks the vein stayed closed. Surface veins are usually mopped up separately.

Usually two to four

Spaced a few weeks apart. Large clusters take more.

Downtime

Walk out, easy for a day or two

Compression stockings for about a week. Walking daily is part of the instructions.

None, and walking is encouraged

Stockings for a week or two. Skip the gym and long standing for a day.

The main downside

Aching, lumps and staining along the vein

A treated trunk vein can feel firm and sore for a few weeks. The rare serious problem is a clot spreading into a deep vein, which is why walking matters.

Brown staining and new tiny veins

A brown line along the treated vein can last months. A blush of new tiny vessels can appear nearby. Both usually fade.

Cost and insurance

One larger fee, often covered

Treating varicose veins that ache, swell or bleed is often covered by insurance.

Priced per session, and it is a course
Both
Insurers usually treat spider vein injections as cosmetic and will not pay for them. For symptomatic varicose veins they commonly want an ultrasound and a few weeks of compression stockings on record first.

The at-home or drugstore version

There is no home version

Nothing sold to the public produces a controlled foam or puts it into a vein under ultrasound.

Stockings and vein creams

Compression stockings ease aching and swelling but remove nothing. Creams cannot reach a vein. Handheld "vein removal" pens act only on the skin surface and can leave marks.

Who each suits

Best for
A leaking trunk vein, especially a twisted one a catheter cannot pass.
The mindset
You want the source dealt with in one appointment, without heat.
Best for
Visible spider veins and small surface veins.
The mindset
You are treating the look of your legs across a few visits.

Varithena is sclerotherapy, scaled up

They are the same idea at different sizes: Both put a drug into a vein to irritate the lining so it seals shut and your body absorbs it.

Foam works on bigger veins because it does not get diluted: A liquid mixes with the blood already in a large vein and loses strength. Foam displaces that blood and stays in contact with the wall.

The ready-made foam is standardised: Hand-mixed foam varies with whoever makes it and breaks down faster. Varithena is made to the same consistency every time, which is the argument for using it in a big vein.

How it compares with heat ablation

Foam and heat close trunk veins at similar rates: Pooled comparisons of the two approaches have not shown a clear winner for keeping the vein shut (pooled analysis of foam versus thermal ablation).

Foam avoids the numbing fluid: Heat ablation needs a line of anaesthetic injected along the whole vein to protect the tissue around it. Foam does not, which is why some people find it easier.

Foam suits veins a catheter struggles with: Very twisted veins, veins close to the skin, and veins that have been treated before are all easier to reach with an injection than with a tube.

What neither one does

Neither one stops new veins forming: Both treat the veins you have today.

Neither removes a bulge you can feel: A vein standing proud of the skin is often better hooked out through tiny nicks, in a procedure called microphlebectomy.

Before you book

Ask what your ultrasound showed, and which vein is being treated.

Ask whether surface spider veins are included or are a separate cost.

Ask how many sessions the plan involves in total.

Ask which parts insurance is likely to cover.

Related

Questions people ask

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Is Varithena the same thing as sclerotherapy?It is a form of it. Varithena is a ready-made foam version of a sclerotherapy drug, aimed at large veins under the skin. Ordinary sclerotherapy uses a liquid on smaller veins you can see.
Can Varithena treat spider veins?It is not used for that. Spider veins are treated with a much weaker liquid injected into the vein you can see.
Is Varithena better than laser or radiofrequency ablation?Pooled comparisons have not shown a clear winner for keeping the vein closed. Foam avoids the line of numbing injections that heat treatments need, and reaches twisted veins a catheter cannot pass.
How many Varithena treatments will I need?Often one per leg, sometimes two. A follow-up ultrasound checks the vein stayed shut. Surface veins usually need separate sessions afterwards.
Does insurance cover Varithena?Often, when the varicose veins cause aching, swelling, itching or bleeding. Insurers commonly want an ultrasound and several weeks of compression stockings first. Spider vein injections are usually treated as cosmetic and not covered.
What are the side effects?Aching, bruising, firm lumps and brown staining along the treated vein are common and settle over weeks. The rare serious problem is a clot spreading into a deep vein, which is why daily walking is part of the aftercare.