Medication

Calcipotriene

Calcipotriene is a lab-made form of vitamin D that you put on the skin. Doctors use it to treat plaque psoriasis, including psoriasis on the scalp.

Topical
Rx Only
Vitamin D Analog

Dermatologist's Take

Calcipotriene is a vitamin D cream that slowly flattens psoriasis plaques without the risks of steroids. It works best when paired with a topical steroid. Skin irritation is the main downside, and overuse can raise blood calcium.

At a glance

  • AKA: Calcipotriol; brand names Dovonex and Sorilux; combined with a steroid in Taclonex and Enstilar
  • Drug Class: Topical vitamin D analog (a lab-made form of vitamin D3)
  • Rx or OTC: Prescription only
  • Typical Dose: Applied to affected skin once or twice a day; do not use more than 100 grams per week
  • Time to Work: Some improvement in 1 to 2 weeks; best results by 6 to 8 weeks
  • Evidence Level: Strong for plaque psoriasis, especially when paired with a topical steroid
  • Important: Using too much can raise the calcium level in your blood

What is it?

What is it text.

How it works

Psoriasis makes skin cells grow and pile up far too fast, which creates thick, scaly patches. Calcipotriene is a form of vitamin D. It signals skin cells to slow down and grow in a more normal way. It also calms some of the immune signals that cause redness and scaling. Over a few weeks, this helps flatten and smooth psoriasis plaques.

What it treats

How it's typically used

Educational overview only — follow your own prescription.

  • Comes as a cream, ointment, solution, or foam.
  • Apply a thin layer to the affected skin once or twice a day, as directed.
  • It is often used together with a topical steroid, sometimes in one combined product (Taclonex, Enstilar).
  • Do not use more than 100 grams per week to lower the risk of high blood calcium.
  • Avoid the face and skin folds unless your doctor tells you otherwise.
  • Wash your hands after applying (unless you are treating your hands).

Common side effects

  • Burning, stinging, itching, or tingling where you apply it
  • Dry or red skin
  • Rash or peeling
  • Worsening of psoriasis in some people
  • Skin that is more sensitive to sunlight

Serious side effects

  • Signs of high blood calcium: nausea, vomiting, constipation, extra thirst or urination, tiredness, confusion, or muscle weakness. This is rare and usually happens only with overuse. Call your doctor.
  • Severe skin irritation, blistering, or swelling
  • Signs of an allergic reaction, such as hives or trouble breathing — seek urgent care

Who shouldn't take it

  • People with high blood calcium or vitamin D toxicity
  • People allergic to calcipotriene
  • Not for use on the face unless a doctor directs it
  • Use with caution if you have a calcium-related disorder or take medicines that affect calcium

Dermapedia Verdict

Frequently asked questions

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