The most effective occlusive there is, with essentially no allergens, for a few dollars. When skin is reacting to everything, this is what still works.

Texture — Thick, greasy ointment
Key Active — Petrolatum 100%
Best For — Extremely dry, cracked, damaged skin; eyelid dermatitis; healing wounds
Price Tier — $
It's worth being clear about how good this genuinely is: nothing outperforms petrolatum at sealing water into skin. It reduces water loss by over 90%. No $200 cream beats it on that measure.
Its real superpower is what it lacks. Almost every skincare reaction traces back to fragrance, preservatives, lanolin, or botanical extracts. Vaseline has none of them. That's why it's the fallback when a patient's skin is reacting to everything — there's nothing in it to react to.
This makes it the correct answer for eyelid dermatitis (where Neosporin and Aquaphor are themselves common allergens and frequently make things worse), for cracked hands, and for healing skin after a procedure.
One technique note: it has no water in it, so it doesn't hydrate on its own — it seals in water that's already there. Apply it to damp skin, or over a moisturizer. Used that way, it's remarkable.
A few dollars, available everywhere, unbeatable at its job.
It's greasy. Genuinely unpleasant under makeup. Most people use it at night, or only on problem areas.
It doesn't hydrate on its own. No water content. Apply to damp skin or over a moisturizer, or you're just sealing in dryness.
Can be too heavy for acne-prone skin on the face — though it's not truly comedogenic for most people, it can feel suffocating.
Don't use it on a fresh burn or an infected wound without medical advice.
📋 1 ingredient · ointment
💧 Petrolatum (100%) (occlusive) — forms a physical seal; reduces water loss by over 90%
ℹ️ Essentially zero allergen risk — which is exactly why it works when nothing else does · ⚠️ No water content — apply over damp skin or on top of a moisturizer
100% petrolatum, and it is the benchmark every other occlusive is measured against.
Petrolatum reduces water loss through the skin by more than 98%. Nothing else comes close — not oils, not silicones, not butters, not coconut oil.
Two things worth knowing.
It does not moisturize. It has no water in it and no humectant. It seals — so it works best applied to skin that is already damp. On bone-dry skin it just sits there.
And unlike Aquaphor, it contains no lanolin. Lanolin was named Allergen of the Year in 2023, and around 3% of patch-tested people react to it. If Aquaphor has ever made things worse instead of better, this is the swap — same job, one fewer allergen, less money.