RESEARCH STUDY

DOMINO: doxycycline 40 mg vs minocycline 100 mg for rosacea (2017)

2017
RCT
80
Moderate

One-line finding

Low-dose doxycycline (40 mg) worked about as well as minocycline (100 mg) for rosacea and caused fewer side effects.

Plain-language summary

This trial directly compared low-dose doxycycline against a standard dose of minocycline (a related tetracycline) in rosacea. Both reduced inflammatory bumps to a similar degree, so doxycycline was "not worse" than minocycline. Doxycycline was linked to fewer side effects, supporting low-dose doxycycline as a first-choice oral option for rosacea.

Citation

van der Linden MMD, van Ratingen AR, van Rappard DC, et al. DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety. Br J Dermatol. 2017;176(6):1465-1474.
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