RESEARCH STUDY

40 mg anti-inflammatory-dose doxycycline for rosacea (phase III, 2007)

2007
RCT
537
High

One-line finding

Once-daily 40 mg doxycycline reduced rosacea bumps more than placebo, with side effects similar to placebo.

Plain-language summary

These two trials tested a low 40 mg daily dose of doxycycline in people with rosacea. The low dose meaningfully reduced inflammatory bumps compared with a dummy pill. Because the dose is too low to act as a full antibiotic, side effects were close to those of placebo. This work supported FDA approval of the 40 mg rosacea formulation (Oracea).

Citation

Del Rosso JQ, Webster GF, Jackson M, et al. Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol. 2007;56(5):791-802.
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