RESEARCH STUDY

International urticaria guideline (2022)

2022
Review
High

One-line finding

Non-drowsy antihistamines are first-line for hives, with higher doses and omalizumab as next steps.

Plain-language summary

A large international panel of experts reviewed the evidence and agreed on how to define, classify, and treat hives (urticaria). They recommend starting with non-drowsy (second-generation) antihistamines, raising the dose if needed, and adding omalizumab for cases that do not respond. This guideline shapes how doctors treat hives worldwide.

Citation

Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766.
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