RESEARCH STUDY

Niacinamide boosts barrier lipids and lowers water loss (2000)

2000
Other
Moderate

One-line finding

Niacinamide boosted skin's production of ceramides and other barrier fats and lowered water loss through the skin.

Plain-language summary

This study showed how niacinamide strengthens the skin barrier. In skin cells, it increased the natural fats (ceramides and fatty acids) that hold the barrier together. On human skin, it reduced water loss and improved dryness. This helps explain why niacinamide is used to support sensitive or dry skin. (PMID/DOI to be confirmed by reviewer.)

Citation

Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000 Sep;143(3):524-31.
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DermaPedia

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Dermapedia is for education only and is not medical advice. It does not create a doctor–patient relationship. Always consult a qualified clinician about your own skin.

© 2026 Dermapedia · Privacy · Terms

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